Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• techniques on the industrial scale, such as microfluidic devices, contributes to their successful clinical translation and reduces the production cost to relatively affordable prices [92][93][94]. The main proportion of lipid-based nanoparticles are liposomes. These are used for the delivery of antitumoral

Silver-based SERS substrates fabricated using a 3D printed microfluidic device

• Phommachith Sonexai,
• Minh Van Nguyen,
• Bui The Huy and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2023, 14, 793–803, doi:10.3762/bjnano.14.65

• NPs are necessary for Ag-based SERS substrates to function well. The microfluidic approach is a technique for the fine control and manipulation of fluids, in which capillary penetration is limited to the micrometer scale and mass transport dominates [9][10]. Microfluidic devices are used in various

• [15][16][17]. Two types of microfluidic devices are commonly used, namely droplet-based and continuous devices. Continuous microfluidic devices have several disadvantages when applied for chemical syntheses, such as laminar flow formation due to the low Reynolds number of fluids, which leads to a lack

• of uniform mixing [18]. In addition, nanoparticles tend to accumulate on the sidewalls of the microfluidic channel, thus limiting the reuse of the device [8][19]. In contrast, droplet-based microfluidic devices are based on the formation of microdroplets using two or more immiscible fluids with

A review on the green and sustainable synthesis of silver nanoparticles and one-dimensional silver nanostructures

• Sina Kaabipour and
• Shohreh Hemmati

Beilstein J. Nanotechnol. 2021, 12, 102–136, doi:10.3762/bjnano.12.9

Out-of-plane surface patterning by subsurface processing of polymer substrates with focused ion beams

• Serguei Chiriaev,
• Luciana Tavares,
• Vadzim Adashkevich,
• Arkadiusz J. Goszczak and
• Horst-Günter Rubahn

Beilstein J. Nanotechnol. 2020, 11, 1693–1703, doi:10.3762/bjnano.11.151

• for the fabrication of a range of microoptical and microfluidic devices and microelectromechanical systems (MEMS). Possible applications of the method for microoptical devices are discussed in detail in our previous work [4]. They include tuning the thickness of the dielectric layer in the metal

Electrokinetic characterization of synthetic protein nanoparticles

• Daniel F. Quevedo,
• Cody J. Lentz,
• Adriana Coll de Peña,
• Yazmin Hernandez,
• Nahal Habibi,
• Rikako Miki,
• Joerg Lahann and
• Blanca H. Lapizco-Encinas

Beilstein J. Nanotechnol. 2020, 11, 1556–1567, doi:10.3762/bjnano.11.138

• and protein compositions to different particle anisotropy (homogenous and anisotropic). Particles were tested in EK microfluidic devices with oval insulating posts, which demonstrated the potential to use EK techniques for the rapid enrichment and characterization of SPNPs. Notably, the results

Use of data processing for rapid detection of the prostate-specific antigen biomarker using immunomagnetic sandwich-type sensors

• Camila A. Proença,
• Tayane A. Freitas,
• Thaísa A. Baldo,
• Elsa M. Materón,
• Flávio M. Shimizu,
• Gabriella R. Ferreira,
• Frederico L. F. Soares,
• Ronaldo C. Faria and
• Osvaldo N. Oliveira Jr.

Beilstein J. Nanotechnol. 2019, 10, 2171–2181, doi:10.3762/bjnano.10.210

• -linked immunosorbent assay. The approaches for immunoassays and data processing are generic, and therefore the strategies described here may provide a simple platform for clinical diagnosis of cancers and other types of diseases. Keywords: cancer biomarkers; magnetite nanoparticles; microfluidic devices

• procedure for a sandwich-type immunomagnetic sensor. Electrochemical immunoassays with disposable microfluidic devices led to excellent linearity, reproducibility, and fast detection at low-cost, while showing excellent agreement with the standard method ELISA. Importantly, the approach for the immunoassays

Rapid, ultraviolet-induced, reversibly switchable wettability of superhydrophobic/superhydrophilic surfaces

• Yunlu Pan,
• Wenting Kong,
• Bharat Bhushan and
• Xuezeng Zhao

Beilstein J. Nanotechnol. 2019, 10, 866–873, doi:10.3762/bjnano.10.87

• sensors, smart filtration and separation, and microfluidic devices [9][10][11][12]. While controlling wettability through heating is mostly limited to toxic materials, such surfaces cannot be applied in human science [13][14]. Although the application of an electric field is an efficient method to achieve

Droplet-based synthesis of homogeneous magnetic iron oxide nanoparticles

• Christian D. Ahrberg,
• Ji Wook Choi and
• Bong Geun Chung

Beilstein J. Nanotechnol. 2018, 9, 2413–2420, doi:10.3762/bjnano.9.226

• mixing, while maintaining high control over the temperature of the sample [21]. Additionally, microfluidic devices can be operated with a high degree of automation allowing for continuous operation, while reaction parameters can be varied easily allowing for automatic screening of reaction conditions [22

• have been synthesized in pinched flow microfluidic geometries, such as fluorescent silica particles [13], or titanium dioxide particles [27]. For these applications, the microfluidic devices were made from poly(dimethylsiloxane) (PDMS) following a soft-lithography fabrication method [28][29], or made

• these microfluidic methods offer advantages over classical batch synthesis, they require expertise in manufacturing and operation of microfluidic devices. To decrease the complexity of microfluidic devices, and to make the technology more accessible to untrained users, devices made from simple tubing

A simple extension of the commonly used fitting equation for oscillatory structural forces in case of silica nanoparticle suspensions

• Sebastian Schön and
• Regine von Klitzing

Beilstein J. Nanotechnol. 2018, 9, 1095–1107, doi:10.3762/bjnano.9.101

• nature of this phenomenon it has implications for a broad range of applications in microfluidic devices, for the stability of colloidal suspensions, or in a biological context, e.g., transport processes between biological surfaces or crystallization of proteins. Confined molecules or particles

Nanoparticle delivery to metastatic breast cancer cells by nanoengineered mesenchymal stem cells

• Liga Saulite,
• Karlis Pleiko,
• Ineta Popena,
• Dominyka Dapkute,
• Ricardas Rotomskis and
• Una Riekstina

Beilstein J. Nanotechnol. 2018, 9, 321–332, doi:10.3762/bjnano.9.32

• and the development of new therapies [15][16]. Generally, a nonadherent surface coating (i.e., polyHEMA), hanging-drop assay or microfluidic devices are used to induce spheroid formation [16][19][20][21]. In the current study, we established a 3D co-culture model using QD-labelled MSCs to verify

Wafer-scale bioactive substrate patterning by chemical lift-off lithography

• Chong-You Chen,
• Chang-Ming Wang,
• Hsiang-Hua Li,
• Hong-Hseng Chan and
• Wei-Ssu Liao

Beilstein J. Nanotechnol. 2018, 9, 311–320, doi:10.3762/bjnano.9.31

• biophysical studies due to its mimetic property toward cell membranes [5][6]. These platforms often use a flat glass surface to support the formation of lipid bilayers via vesicle fusion. With the combination of microfluidic devices and lithographic techniques, the creation of multiplexed arrays has been

Patterning of supported gold monolayers via chemical lift-off lithography

• Liane S. Slaughter,
• Kevin M. Cheung,
• Sami Kaappa,
• Huan H. Cao,
• Qing Yang,
• Thomas D. Young,
• Andrew C. Serino,
• Sami Malola,
• Jana M. Olson,
• Stephan Link,
• Hannu Häkkinen,
• Anne M. Andrews and
• Paul S. Weiss

Beilstein J. Nanotechnol. 2017, 8, 2648–2661, doi:10.3762/bjnano.8.265

• functionality without affecting the flexibility or transparency of PDMS. Incorporating chemical functionality onto PDMS will be useful for integrating sensing functions into microfluidic devices [68][69][70][71][72][73][74][75][76][77][78][79][80]. Compared with many techniques used to impart sub-micrometer

Micro- and nano-surface structures based on vapor-deposited polymers

• Hsien-Yeh Chen

Beilstein J. Nanotechnol. 2017, 8, 1366–1374, doi:10.3762/bjnano.8.138

• uniformity with reduced array-to-array variation [19]. Vapor-phased plasma polymerization to prepare polyacrylic acid has also used to pattern and functionalize microfluidic devices based on wet and dry etching techniques [20]. Combining plasma polymerization and lithographical processes has also been used

Vapor deposition routes to conformal polymer thin films

• Priya Moni,
• Ahmed Al-Obeidi and
• Karen K. Gleason

Beilstein J. Nanotechnol. 2017, 8, 723–735, doi:10.3762/bjnano.8.76

• CVD both in conformality and functional group retention for the deposition of conformal sensing molecules on microfluidic devices [30]. This concept was later used to enable PDMS-free microfluidic devices for oxygen-free flow-lithography, a process that can generate multifunctional micro and nano

Microfluidic setup for on-line SERS monitoring using laser induced nanoparticle spots as SERS active substrate

• Oana-M. Buja,
• Ovidiu D. Gordan,
• Nicolae Leopold,
• Andreas Morschhauser,
• Jörg Nestler and
• Dietrich R. T. Zahn

Beilstein J. Nanotechnol. 2017, 8, 237–243, doi:10.3762/bjnano.8.26

• processes within the enclosed channels and using small amounts of solutions. The integration of the SERS technique with microfluidic systems [12][13] shows great potential for analytical studies as lab-on-chip SERS. Even if various studies demonstrated the SERS detection within microfluidic devices [12][13

Novel roles for well-known players: from tobacco mosaic virus pests to enzymatically active assemblies

• Claudia Koch,
• Fabian J. Eber,
• Carlos Azucena,
• Alexander Förste,
• Stefan Walheim,
• Thomas Schimmel,
• Alexander M. Bittner,
• Holger Jeske,
• Hartmut Gliemann,
• Sabine Eiben,
• Fania C. Geiger and
• Christina Wege

Beilstein J. Nanotechnol. 2016, 7, 613–629, doi:10.3762/bjnano.7.54

• the fabrication of microfluidic devices by master-replication techniques, was already shown to allow a site-specific bottom-up integration of TMV carrier sticks [60]. This was achieved via isothiocyanate- (ITC-) based coupling of single-stranded (ss) DNA anchors, subsequent trapping of the 3'-ends of

• channels of microfluidic devices in operation (for typical layouts and flow rates see [177]). To ensure robust implantation, full accessibility and constant spacing, ongoing work is attempting to fix TMV adapter sticks in upright positions. Initial results indicate that nanopatterned metal-organic layers

Selective porous gates made from colloidal silica nanoparticles

• Roberto Nisticò,
• Paola Avetta,
• Paola Calza,
• Debora Fabbri,
• Giuliana Magnacca and
• Dominique Scalarone

Beilstein J. Nanotechnol. 2015, 6, 2105–2112, doi:10.3762/bjnano.6.215

• separation processes and dosing of chemicals. In this study, the surface functionalization of silicon nitride commercial microsieves by means of colloidal silica nanoparticles has been proposed as a novel strategy to fabricate composite membranes for microfluidic devices. The permeability and size

A surface acoustic wave-driven micropump for particle uptake investigation under physiological flow conditions in very small volumes

• Florian G. Strobl,
• Dominik Breyer,
• Phillip Link,
• Adriano A. Torrano,
• Christoph Bräuchle,
• Matthias F. Schneider and
• Achim Wixforth

Beilstein J. Nanotechnol. 2015, 6, 414–419, doi:10.3762/bjnano.6.41

• produce. However, the shear rates that were reported so far for “conventional” SAW-driven microfluidic devices are usually one or two orders of magnitude below the typical shear rates of the capillary system and therefore not suitable for mimicking capillary blood flow. High input power to the SAW

Tunable light filtering by a Bragg mirror/heavily doped semiconducting nanocrystal composite

• Ilka Kriegel and
• Francesco Scotognella

Beilstein J. Nanotechnol. 2015, 6, 193–200, doi:10.3762/bjnano.6.18

• : active optical component; electronic band gap nanostructure; localized surface plasmon resonance; photonic crystal; Introduction Optical filters are fundamental components employed in almost all optical setups and devices. For example, they play a very important role in microfluidic devices, which are

• very interesting for point-of-care diagnostics [1][2]. Very interesting strategies to fabricate colour filters, without auto-fluorescence, are proposed in the literature [3]. However, in many applications, such as in microfluidic devices, where the detection of more than one analyte is often necessary

Energy transfer in complexes of water-soluble quantum dots and chlorin e6 molecules in different environments

• Irina V. Martynenko,
• Anna O. Orlova,
• Vladimir G. Maslov,
• Alexander V. Baranov,
• Anatoly V. Fedorov and
• Mikhail Artemyev

Beilstein J. Nanotechnol. 2013, 4, 895–902, doi:10.3762/bjnano.4.101

• (ethylene terephthalate) track membranes that can be utilized as an element of microfluidic devices [8]. Experimental Chemicals Bis-N-methyl-D-glucamine salt of chlorin e6 (photosensitizer “Photoditazin”) was purchased from VETA Grand Ltd. Photoditazin has a QY of 9% in aqueous solution. Trioctylphosphine

Porous polymer coatings as substrates for the formation of high-fidelity micropatterns by quill-like pens

• Michael Hirtz,
• Marcus Lyon,
• Wenqian Feng,
• Andrea E. Holmes,
• Harald Fuchs and
• Pavel A. Levkin

Beilstein J. Nanotechnol. 2013, 4, 377–384, doi:10.3762/bjnano.4.44

• techniques [1]. For scales of 100 µm and above, even plain paper was proposed as an inexpensive substrate for microfluidic devices [2][3]. However, when downsizing microarrays to the lower micrometer range with spot features in the range of a few tens of micrometres, the intrinsic granularity and broad pore

Continuous parallel ESI-MS analysis of reactions carried out in a bespoke 3D printed device

• Jennifer S. Mathieson,
• Mali H. Rosnes,
• Victor Sans,
• Philip J. Kitson and
• Leroy Cronin

Beilstein J. Nanotechnol. 2013, 4, 285–291, doi:10.3762/bjnano.4.31

• has been coupled to microfluidic devices as an in-line analytical technique [15][16][17]. In these instances all the flow was fed directly to the MS to ensure high enough flow and concentration for efficient detection, but whereby the sample cannot be regenerated due to the nature of MS. Examples also

Ultraviolet photodetection of flexible ZnO nanowire sheets in polydimethylsiloxane polymer

• Jinzhang Liu,
• Nunzio Motta and
• Soonil Lee

Beilstein J. Nanotechnol. 2012, 3, 353–359, doi:10.3762/bjnano.3.41

• ), which is an optically clear, UV-transparent silicone polymer that has been used in the fabrication of contact lenses, microfluidic devices, and stretchable displays. Due to its excellent gas permeability this polymer has been applied as a membrane for gas separation [15]. In our work, we combine free

Analysis of fluid flow around a beating artificial cilium

• Mojca Vilfan,
• Gašper Kokot,
• Andrej Vilfan,
• Natan Osterman,
• Blaž Kavčič,
• Igor Poberaj and
• Dušan Babič

Beilstein J. Nanotechnol. 2012, 3, 163–171, doi:10.3762/bjnano.3.16

• designing artificial cilia that would act as pumps and mixers in microfluidic devices. The artificial cilia would be periodically driven by an external force, for example by an electric or a magnetic field, and as long as it beats in an asymmetric manner, it should generate flow. Initial attempts to create

Review and outlook: from single nanoparticles to self-assembled monolayers and granular GMR sensors

• Alexander Weddemann,
• Inga Ennen,
• Anna Regtmeier,
• Camelia Albon,
• Annalena Wolff,
• Katrin Eckstädt,
• Nadine Mill,
• Michael K.-H. Peter,
• Jochen Mattay,
• Carolin Plattner,
• Norbert Sewald and
• Andreas Hütten

Beilstein J. Nanotechnol. 2010, 1, 75–93, doi:10.3762/bjnano.1.10

• chemical, physical and medical fields [1]. A common example is their employment in microfluidic devices: Due to their permanent magnetic moment, they can be controlled via external, inhomogeneous magnetic fields [2] and also be detected by magnetoresistive sensors [3] which allows for the magneto-based